It's understood he sustained critical injuries in a car crash while he was fleeing East London following the attack on Leighandre Jegels and her mother on Friday.
Swiss 23rd seed and 2016 champion Wawrinka led Djokovic 6-4, 7-5, 2-1 when the Serb quit, having received treatment on his troublesome left shoulder before the start of the third set.
Unai Emery's side were in danger of a damaging defeat after goals from Christian Eriksen and Harry Kane put Tottenham in control by the 40th minute at the Emirates Stadium.