Warren Whiteley failed a fitness test at the Lions captains run on Thursday and will be replaced by Kwagga Smith in the line-up.
Kaizer Chiefs have confirmed that they reached a mutual agreement with Hendrick Ekstein to terminate his contract.
The world champion 400m runner was due to make his return in the 400m heats on Thursday afternoon.
There are seven changes to the starting line-up, with four in the forward pack and three in the backline.
Proposals to change the Champions League after 2024 have triggered opposition from several leading European football leagues.
US and Australian Open champion Osaka, who lost to Taiwanese veteran Hsieh in Miami last month, secured a place in the quarter-finals against Croatia's Donna Vekic.
Legendary Proteas all-rounder Jacques Kallis has been bestowed an Order of Ikhamanga in the silver division by President Cyril Ramaphosa for his contribution to cricket and the role he has played in putting South Africa on the world sports map.
The Springboks have revealed their 2019 Rugby Cup jersey that they will play in, in Japan in September.
In the other early match, seventh seeded Russian Daniil Medvedev beat American Mackenzie McDonald 6-3, 6-2.
As has been the case in the past, the iconic Springbok logo on the jersey will move to the left sleeve of the jersey to accommodate the official Rugby World Cup logo on the left breast.
